DTPA-bisamide-based MR sensor agents for peroxidase imaging

被引：93

作者：

Querol, M

Chen, JW

Weissleder, R

Bogdanov, A

机构：

[1] Massachusetts Gen Hosp, Ctr Mol Imaging Res, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 09期

关键词：

D O I：

10.1021/ol050208v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and some properties of two novel DTPA-bisamides are reported. These derivatives were designed as enzyme-activated contrast agents (CA) for magnetic resonance imaging. Both derivatives bear tyramido or 5-hydroxytryptamido groups that could be oligomerized in situ in the presence of peroxidase/H2O2 pair resulting in a net increase in longitudinal (R1) relaxivity.

引用

页码：1719 / 1722

页数：4

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