Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients

被引：38

作者：

Alegretti, A. P. ^{[1
]}

Mucenic, T. ^{[2
]}

Merzoni, J. ^{[3
]}

Faulhaber, G. A. ^{[4
]}

Silla, L. M. ^{[5
]}

Xavier, R. M. ^{[2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Serv Patol Clin, BR-90035903 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Serv Reumatol, BR-90035903 Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Fac Farm, BR-90035903 Porto Alegre, RS, Brazil

[4] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Med Interna Serv, BR-90035903 Porto Alegre, RS, Brazil

[5] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Serv Hematol Clin, BR-90035903 Porto Alegre, RS, Brazil

来源：

CELLULAR IMMUNOLOGY | 2010年 / 265卷 / 02期

关键词：

Systemic lupus erythematosus; SLE; CD55; CD59; Lymphopenia; Cytopenias; Complement system; GPI; Flow cytometry; Immunophenotyping; COMPLEMENT REGULATORY PROTEINS; DIMINISHED EXPRESSION; 2; PARTS; ACTIVATION; LYMPHOPENIA; IMMUNOLOGY; PATHWAY; DISEASE; CD46;

D O I：

10.1016/j.cellimm.2010.07.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

CD55 and CD59 are glycosylphosphatidylinositol-anchored proteins with complement inhibitory properties. CD55 inhibits the formation of C3 convertases, and CD59 prevents the terminal polymerisation of the membrane attack complex. It has been reported that SLE patients seems to have an acquired deficiency of these proteins associated with secondary autoimmune haemolytic anaemia and lymphopenia. The aim of this study was to evaluate the presence of altered CD55 and CD59 expression on peripheral blood cells from SLE patients. Flow cytometric analyses were performed on red and white blood cells from 23 SLE patients and 23 healthy controls. We observed more CD55- and CD59-lymphocytes (p = 0.005 and p = 0.019, respectively), and CD59-granulocytes (p = 0.045) in SLE patients than in controls. These results suggest there is an altered pattern of CD55 and CD59 expression on the peripheral blood cells of SLE patients, and it may play a role in the cytopenias in these patients. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：127 / 132

页数：6

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