Constitutively active G protein-coupled receptor mutants: Implications on receptor function and drug action

被引：12

作者：

Cotecchia, S

Fanelli, F

Costa, T

机构：

[1] Univ Lausanne, Inst Pharmacol & Toxicol, CH-1005 Lausanne, Switzerland

[2] Univ Modena & Reggio Emilia, Dulbecco Telethon Inst, Modena, Italy

[3] Univ Modena & Reggio Emilia, Dept Chem, Modena, Italy

[4] Ist Super Sanita, I-00161 Rome, Italy

来源：

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES | 2003年 / 1卷 / 02期

关键词：

D O I：

10.1089/15406580360545125

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutations of GPCRs can increase their constitutive (agonist-independent) activity. Some of these mutations have been artificially introduced by site-directed mutagenesis; others occur spontaneously in human diseases. The analysis of constitutively active GPCR mutants has attracted a large interest in the past decade, providing an important contribution to our understanding of the molecular mechanisms underlying receptor function and drug action.

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收藏

页码：311 / 316

页数：6

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