DNA-catalyzed formation of nucleopeptide linkages

被引：68

作者：

Pradeepkumar, P. I. ^{[1
]}

Hobartner, Claudia ^{[1
]}

Baum, Dana A. ^{[1
]}

Silverman, Scott K. ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 09期

关键词：

amino acids; deoxyribozymes; DNA; in vitro selection; nucleopeptides;

D O I：

10.1002/anie.200703676

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Joining amino acids and nucleotides: A deoxyribozyme catalyzes the nucleophilic attack of a tyrosine (Tyr) side chain on a 5′-triphosphate RNA, efficiently forming a Tyr-RNA nucleopeptide linkage (see picture). Thus, the scope of known DNA catalysis is further expanded beyond reactions of oligonucleotide functional groups. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1753 / 1757

页数：5

共 53 条

[1] DNAzymes:: From creation in vitro to application in vivo [J].

Achenbach, JC ;

Chiuman, W ;

Cruz, RPG ;

Li, Y .

CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2004, 5 (04) :321-336

[2]

ADLER SP, 1975, J BIOL CHEM, V250, P6264

[3]

AMBROS V, 1978, J BIOL CHEM, V253, P5263

[4] A ribozyme that ligates RNA to protein [J].

Baskerville, S ;

Bartel, DP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (14) :9154-9159

[5]

Baum D. A., 2007, ANGEW CHEM, V119, P3572

[6] Deoxyribozyme-catalyzed labeling of RNA [J].

Baum, Dana A. ;

Silverman, Scott K. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (19) :3502-3504

[7]

Breaker R R, 1994, Chem Biol, V1, P223, DOI 10.1016/1074-5521(94)90014-0

[8] Cofactor-assisted self-cleavage in DNA libraries with a 3'-5'-phosphoramidate bond [J].

Burmeister, J ;

vonKiedrowski, G ;

Ellington, AD .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (12) :1321-1324

[9]

BURMEISTER J, 1997, ANGEW CHEM, V109, P1379

[10] Cleaving DNA with DNA [J].

Carmi, N ;

Balkhi, SR ;

Breaker, RR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2233-2237

← 1 2 3 4 5 6 →