The Vascular Effects of Infection in Pediatric Stroke (VIPS) Study

被引：59

作者：

Fullerton, Heather J. ^{[1
]}

Elkind, Mitchell S. V. ^{[2
,3
,4
]}

Barkovich, A. James ^{[5
]}

Glaser, Carol ^{[6
,7
]}

Glidden, David ^{[8
]}

Hills, Nancy K. ^{[1
]}

Leiva-Salinas, Carlos ^{[9
]}

Wintermark, Max ^{[9
]}

deVeber, Gabrielle A. ^{[10
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[2] Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA

[3] Columbia Univ Coll Phys & Surg, Dept Epidemiol, New York, NY 10032 USA

[4] Mailman Sch Publ Hlth, New York, NY USA

[5] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

[7] Dept Publ Hlth, Oakland, CA USA

[8] Univ Calif San Francisco, Dept Biostat & Epidemiol, San Francisco, CA 94143 USA

[9] Univ Virginia, Dept Radiol, Charlottesville, VA USA

[10] Hosp Sick Children, Dept Neurol, Toronto, ON M5G 1X8, Canada

来源：

JOURNAL OF CHILD NEUROLOGY | 2011年 / 26卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Vascular Effects of Infection in Pediatric Stroke (VIPS); arteriopathy; inflammation; vasculitis; C-REACTIVE PROTEIN; ARTERIAL ISCHEMIC-STROKE; VARICELLA-ZOSTER-VIRUS; CENTRAL-NERVOUS-SYSTEM; TRANSIENT CEREBRAL ARTERIOPATHY; MAGNETIC-RESONANCE ANGIOGRAPHY; APPARENTLY HEALTHY-MEN; MYOCARDIAL-INFARCTION; RISK-FACTORS; CEREBROVASCULAR-DISEASE;

D O I：

10.1177/0883073811408089

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Understanding the vascular injury pathway is crucial to developing rational strategies for secondary stroke prevention in children. The multicenter Vascular Effects of Infection in Pediatric Stroke (VIPS) cohort study will test the hypotheses that (1) infection can lead to childhood arterial ischemic stroke by causing vascular injury and (2) resultant arteriopathy and inflammatory markers predict recurrent stroke. The authors are prospectively enrolling 480 children (aged 1 month through 18 years) with arterial ischemic stroke and collecting extensive infectious histories, blood and serum samples (and cerebrospinal fluid, when clinically obtained), and standardized brain and cerebrovascular imaging studies. Laboratory assays include serologies (acute and convalescent) and molecular assays for herpesviruses and levels of inflammatory markers. Participants are followed prospectively for recurrent ischemic events (minimum of 1 year). The analyses will measure association between markers of infection and cerebral arteriopathy and will assess whether cerebral arteriopathy and inflammatory markers predict recurrent stroke.

引用

页码：1101 / 1110

页数：10

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