Resolution of 2-aryloxy-1-propanols via lipase-catalyzed enantioselective acylation in organic media

被引：14

作者：

Miyazawa, T ^{[1
]}

Yukawa, T

Koshiba, T

Sakamoto, H

Ueji, S

Yanagihara, R

Yamada, T

机构：

[1] Konan Univ, Fac Sci & Engn, Dept Chem, Higashinada Ku, Kobe, Hyogo 6588501, Japan

[2] Kobe Univ, Fac Human Dev & Sci, Div Nat Environm & Bioorgan Chem, Nada Ku, Kobe, Hyogo 6578501, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(01)00258-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

2-Aryloxy-1-propanols, primary alcohols with an oxygyen atom at the stereocenter. were resolved with good to high enantioselectivity by acylation with vinyl butanoate mediated by Pseudomonas sp. lipase in di-iso-propyl ether. Potential factors affecting the enantioselectivity of the enzymatic acylation were examined: solvents. acyl donors mid temperature, Using this enantioselective acylation procedure. enantiomeriocally pure (R)-2-(4-chlorophenoxy)-1-propanol was prepared on a grain scale. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1595 / 1602

页数：8

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