Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss

被引：143

作者：

Guelmez, Dolunay ^{[1
,2
]}

Woodford, Neil ^{[2
]}

Palepou, Marie-France I. ^{[2
]}

Mushtaq, Shazad ^{[2
]}

Metan, Gokhan ^{[1
,3
]}

Yakupogullari, Yusuf ^{[4
,5
]}

Kocagoz, Sesin ^{[6
]}

Uzun, Omrum ^{[7
]}

Hascelik, Gulsen ^{[1
]}

Livermore, David M. ^{[2
]}

机构：

[1] Hacettepe Univ, Fac Med, Dept Microbiol & Clin Microbiol, TR-06100 Ankara, Turkey

[2] Ctr Infect Hlth Protect Agcy, Antibiot Resistance Monitoring & Reference Lab, London, England

[3] Erciyes Univ, Fac Med, Dept Infect & Clin Microbiol, Kayseri, Turkey

[4] Firat Univ, Fac Med, Dept Microbiol & Clin Microbiol, TR-23169 Elazig, Turkey

[5] Malatya State Hosp, Dept Microbiol & Clin Microbiol, Malatya, Turkey

[6] Yeditepe Univ, Fac Med, Dept Microbiol & Clin Microbiol, Istanbul, Turkey

[7] Hacettepe Univ, Fac Med, Dept Internal Med, Infect Dis Sect, TR-06100 Ankara, Turkey

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2008年 / 31卷 / 06期

关键词：

Escherichia coli; Klebsiella pneumoniae; carbapenem resistance; carbapenemase; OXA-48; CTX-M ESBL;

D O I：

10.1016/j.ijantimicag.2008.01.017

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Treatment options are limited in infections caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, with carbapenems generally preferred. Disturbingly, however, carbapenem-resistant strains are emerging worldwide. Here we report two clinical isolates, one Escherichia coli and one Klebsiella pneumoniae, each with high-level carbapenem resistance (imipenem minimum inhibitory concentration of 32 mu g/mL). They were isolated following imipenem therapy from two hospital patients who had received imipenem therapy in different regions of Turkey. Both isolates produced OXA-48-like carbapenemases, enzymes so far reported only from Turkey. Both isolates also had group 1 CTX-M-type ESBLs and had lost major outer membrane proteins. OXA-48-like carbapenemases appear to be scattered in Turkey and surveillance to determine their prevalence is warranted. (c) 2008 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：523 / 526

页数：4

共 31 条

[1] ALTSHUL SF, 1997, NUCLEIC ACIDS RES, V25, P402
[2] BSAC standardized disc susceptibility testing method (version 5)
Andrews, J. M.
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (03) : 511 - 529
[3] IS1999 increases expression of the extended-spectrum β-lactamase VEB-1 in Pseudomonas aeruginosa
Aubert, D
Naas, T
Nordmann, P
[J]. JOURNAL OF BACTERIOLOGY, 2003, 185 (17) : 5314 - 5319
[4] BIMBOIM HC, 1979, NUCLEIC ACIDS RES, V7, P1613
[5] Chromosome-encoded class D β-lactamase OXA-23 in Proteus mirabilis
Bonnet, R
Marchandin, H
Chanal, C
Sirot, D
Labia, R
De Champs, C
Jumas-Bilak, E
Sirot, J
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) : 2004 - 2006
[6] Extended-spectrum β-lactamases in the 21st century:: Characterization, epidemiology, and detection of this important resistance threat
Bradford, PA
[J]. CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (04) : 933 - 951
[7] Chart H., 1994, METHODS PRACTICAL LA
[8] *CLIN LAB STAND I, 2005, PERF STAND ANT S S15
[9] Occurrence of carbapenern-resistant Acinetobacter baumannii clones at multiple hospitals in London and southeast England
Coelho, Juliana M.
Turton, Jane F.
Kaufmann, Mary E.
Glover, Judith
Woodford, Neil
Warner, Marina
Palepou, Marie-France
Pike, Rachel
Pitt, Tyrone L.
Patel, Bharat C.
Livermore, David M.
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (10) : 3623 - 3627
[10] Multiplex PCR for rapid detection of genes encoding acquired metallo-β-lactamases
Ellington, Matthew J.
Kistler, James
Livermore, David M.
Woodford, Neil
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 59 (02) : 321 - 322

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