Disruption of protein-protein interactions:: design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

被引：54

作者：

Wei, Y ^{[1
]}

McLendon, GL

Hamilton, AD

Case, MA

Purring, CB

Lin, Q

Park, HS

Lee, CS

Yu, TN

机构：

[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

[2] Drexel Univ, Dept Chem, Philadelphia, PA 19104 USA

[3] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 17期

关键词：

D O I：

10.1039/b104142h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic receptor I has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1:1 Cc:1 complex with a binding constant of (3 +/- 1) X 10(8) M-1, and to disrupt Cc: Apaf-1 complex, a key adduct in apoptosis.

引用

页码：1580 / 1581

页数：2

共 16 条

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