Transgenerational epigenetic inheritance: More questions than answers

被引:164
作者
Daxinger, Lucia [1 ]
Whitelaw, Emma [1 ]
机构
[1] Queensland Inst Med Res, Epigenet Lab, Brisbane, Qld 4006, Australia
基金
奥地利科学基金会;
关键词
MATERNAL METHYL SUPPLEMENTS; POSITION-EFFECT VARIEGATION; DEPENDENT RNA-POLYMERASE; DNA METHYLATION; GENE-EXPRESSION; TRANSPOSABLE ELEMENTS; MONOZYGOTIC TWIN; PARAMUTATION; CHROMATIN; GENOME;
D O I
10.1101/gr.106138.110
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epigenetic modifications are widely accepted as playing a critical role in the regulation of gene expression and thereby contributing to the determination of the phenotype of multicellular organisms. In general, these marks are cleared and re-established each generation, but there have been reports in a number of model organisms that at some loci in the genome this clearing is incomplete. This phenomenon is referred to as transgenerational epigenetic inheritance. Moreover, recent evidence shows that the environment can stably influence the establishment of the epigenome. Together, these findings suggest that an environmental event in one generation could affect the phenotype in subsequent generations, and these somewhat Lamarckian ideas are stimulating interest from a broad spectrum of biologists, from ecologists to health workers.
引用
收藏
页码:1623 / 1628
页数:6
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