Synthesis of pyrrolobenzodiazepines via the PIFA oxidation of amines. Synthesis of 8-deoxy DC-81

被引：21

作者：

Kraus, GA ^{[1
]}

Melekhov, A ^{[1
]}

机构：

[1] Iowa State Univ Sci & Technol, Dept Chem, Ames, IA 50011 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 39期

关键词：

D O I：

10.1016/S0040-4020(98)83036-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

PIFA can be used to introduce the imine moiety into a precursor to the pyrrolobenzodiazepines in 62% yield. This oxidation completes an efficient four-step synthesis of 8-deoxy DC-81. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：11749 / 11754

页数：6

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