Physical and biological properties of a novel hydrogel composite based on oxidized alginate, gelatin and tricalcium phosphate for bone tissue engineering

被引：47

作者：

Cai, Kaiyong ^{[1
]}

Zhang, Jun ^{[1
]}

Deng, Lin Hong ^{[1
]}

Yang, Li ^{[1
]}

Hu, Yon ^{[1
]}

Chen, Cong ^{[1
]}

Xue, Lei ^{[1
]}

Wang, Lu ^{[1
]}

机构：

[1] Chongqing Univ, Coll Bioengn, Res Ctr Biomat & Biomimet engn, Chongqing 400044, Peoples R China

来源：

ADVANCED ENGINEERING MATERIALS | 2007年 / 9卷 / 12期

关键词：

D O I：

10.1002/adem.200700222

中图分类号：

T [工业技术];

学科分类号：

08 [工学];

摘要：

A novel hydrogel composite based on oxidized alginate, gelatin and tricalcium phosphate (TCP) that shows the physio-chemical and biological properties of the bone was analyzed. Morphologies of wet state and lyophilized cross-linked oxidized alginate, gelatine and TCP hydrogel composite were investigated by using a commercial camera and scanning electron microscopy. The water uptake capacities of hydrogel composites were determined by swelling them in phosphate buffered saline (PBS) at room temperature. Oxidized alginate, gelatin and TCP were sterilized using ethylene oxide according to standard protocol. The hydrogel composite was proved to be a potential drug delivery carrier with controlled biodegradable property. The hydrgel composites are the appropriate candidates for bone tissue engineering and other medical applications.

引用

页码：1082 / 1088

页数：7

共 33 条

[1]

Evaluation of the effect of incorporation of dibutyryl cyclic adenosine monophosphate in an in situ-forming hydrogel wound dressing based on oxidized alginate and gelatin [J].