Prominin-1 (CD133): from progenitor cells to human diseases

被引：65

作者：

Fargeas, Christine A. ^{[1
]}

Fonseca, Ana-Violeta ^{[1
]}

Huttner, Wieland B. ^{[1
]}

Corbeil, Denis ^{[1
]}

机构：

[1] Tech Univ Dresden, Tissue Engn Labs, BIOTEC, D-01307 Dresden, Germany

来源：

FUTURE LIPIDOLOGY | 2006年 / 1卷 / 02期

关键词：

AC133; antigen; bone marrow transplantation; cancer; CD; 133; cholesterol; hematopoietic; lipid raft; progenitors; prominin-1; retinal degeneration; stem cell marker;

D O I：

10.2217/17460875.1.2.213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prominin-1 (CD133) is a pentaspan membrane glycoprotein that binds to plasma membrane cholesterol and concentrates selectively in plasma membrane protrusions. In recent years, this molecule has received considerable interest due to its expression in various progenitors, including those derived from the neural and hematopoietic system, as well as in cancer originating from these systems. Prominin-1 is also the target of mutations leading to retinal degeneration. In the future, prominin-1-positive progenitor cells might become clinically significant, particularly with regard to tissue engineering, and prominin-1 itself might reveal some fundamental cell biological aspects concerning the self-renewal capacity of somatic stem cells.

引用

页码：213 / 225

页数：13

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