Total synthesis of caprazol, a core structure of the caprazamycin antituberculosis antibiotics

被引：98

作者：

Hirano, S ^{[1
]}

Ichikawa, S ^{[1
]}

Matsuda, A ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 12期

关键词：

antibiotics; glycosylation; heterocycles; natural products; total synthesis;

D O I：

10.1002/anie.200462439

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

TB and anti-TB: Two key steps in the synthesis of caprazol (1), a core structure of the antituberculosis antibiotics, are the introduction of an aminoribose moiety by β-selective ribosylation without the use of neighboring-group participation and the construction of the diazepanone moiety. (Chemical Equation Presented) © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1854 / 1856

页数：3

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