Synthesis of 1,8-naphthyridine C-nucleosides and their base-pairing properties in oligodeoxynucleotides:: Thermally stable Naphthyridine:Imidazopyridopyrimidine base-pairing motifs

被引：68

作者：

Hikishima, S ^{[1
]}

Minakawa, N ^{[1
]}

Kuramoto, K ^{[1
]}

Fujisawa, Y ^{[1
]}

Ogawa, M ^{[1
]}

Matsuda, A ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 04期

关键词：

DNA recognition; hydrogen bonds; nucleobases; nucleosides; oligonucleotides;

D O I：

10.1002/anie.200461857

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Out with the old, in with the new: Novel 1,8-naphthyridine C-nucleosides, Na-NO and Na-ON (see formulae), were synthesized through Heck coupling reactions. Oligodeoxynucleotides containing the Na-NO and Na-ON nucleosides formed extremely stable duplexes by the base-pairing motifs Na-NO:Im-ON and Na-O N:Im-NO.

引用

页码：596 / 598

页数：3

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