A convenient synthesis of N-acylpyrroles from primary aromatic amides

被引：20

作者：

Ekkati, AR ^{[1
]}

Bates, DK ^{[1
]}

机构：

[1] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA

来源：

SYNTHESIS-STUTTGART | 2003年 / 13期

关键词：

N-acylpyrroles; primary amides; condensation; 2,5-dimethoxytertahydrofuran;

D O I：

10.1055/s-2003-41020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of N-acylpyrroles in 45-85% isolated yield from primary aromatic amides and excess 2,5-dimethoxytetrahydrofuran in presence of one equivalent of thionyl chloride is reported. This method has several advantages including short reaction times, mild reaction conditions, and easy workup. The technique works particularly well for deactivated aromatic amides.

引用

页码：1959 / 1961

页数：3

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