Synthesis of C-aryl and C-alkyl glycosides using glycosyl phosphates

被引：65

作者：

Palmacci, ER ^{[1
]}

Seeberger, PH ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 10期

关键词：

D O I：

10.1021/ol0158462

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Mannosyl and glucosyl phosphate donors were successfully used in constructing C-aryl linkages common to many natural products via a Lewis acid induced Fries like rearrangement, The rearrangement was stereo and regiospecific, yielding only one C-glycoside product. C-Alkyl glycoside carbohydrate mimetics were generated by using silicon derived C-nucleophiles and glycosyl phosphates.

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页码：1547 / 1550

页数：4

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