Sequential N-acylamide methylenation-enamide ring-closing metathesis:: a synthetic entry to 1,4-dihydroquinolines

被引:39
作者
Bennasar, ML [1 ]
Roca, T [1 ]
Monerris, M [1 ]
García-Díaz, D [1 ]
机构
[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain
关键词
dimethyltitanocene; olefination; enamides; ring-closing metathesis; 1,4-dihydroquinolines;
D O I
10.1016/j.tetlet.2005.04.028
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new synthetic entry to the 1,4-dihydroquinoline nucleus is reported. The procedure involves the dimethyltitanocene methylenation of N-(alkoxycarbonyl)amides derived from 2-allylanilines, followed by ring-closing metathesis of the resulting enamides. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码:4035 / 4038
页数:4
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