Aminoglycoside-hybrid ligands targeting the ribosomal decoding site

被引：36

作者：

Vourloumis, D

Winters, GC

Simonsen, KB

Takahashi, M

Ayida, BK

Shandrick, S

Zhao, Q

Han, Q

Hermann, T

机构：

[1] Anadys Pharmaceut Inc, Dept Med Chem, San Diego, CA 92121 USA

[2] Anadys Pharmaceut Inc, Dept Struct Chem, San Diego, CA 92121 USA

来源：

CHEMBIOCHEM | 2005年 / 6卷 / 01期

关键词：

aminoglycosides; antibiotics; drug design; medicinal chemistry; RNA recognition;

D O I：

10.1002/cbic.200400197

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial bridges: RNA helix 44 within the small subunit of the bacterial ribosome is the target for natural aminoglycoside antibiotics of the neomycin and hygromycin classes, which bind at neighboring sites and thereby interfere with protein synthesis. We describe synthetic aminoglycoside-hybrid ligands, such as 1, designed to inhibit translation by bridging between the neamine and hygromycin binding sites.

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收藏

页码：58 / 65

页数：8

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