Micro-structured reactors as a tool for chiral modifier screening in gas-liquid-solid asymmetric hydrogenations

被引：13

作者：

Abdallah, Radwan ^{[1
]}

Fumey, Bruno ^{[1
]}

Meille, Valerie ^{[1
]}

de Bellefon, Claude ^{[1
]}

机构：

[1] ESCPE Lyon, CNRS, Lab Genie Procedes Catalyt, F-69616 Villeurbanne, France

来源：

CATALYSIS TODAY | 2007年 / 125卷 / 1-2期

关键词：

high throughput screening; micro-reactor; heterogeneous catalysis; ligand library; asymmetric hydrogenation; ethylpyruvate; chiral modifiers;

D O I：

10.1016/j.cattod.2007.01.055

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A continuous micro-structured reactor equipped with a perforated (5 mu m) membrane is used for the investigation of the gas-liquid-solid asymmetric hydrogenation of ethylpyruvate, on a Pt-gamma-Al2O3 catalyst modified with chiral inductors under high hydrogen pressure (45 bar). Up to eight chiral inductors have been evaluated, the best enantioselectivity (63%) being obtained with cinchonidine. The very low reaction volume (100 mu 1) offers short operating time. Solvent effect, deactivation studies and the effect of modifier leaching are also reported. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：34 / 39

页数：6

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