A fork in the pathway to inflammation and arthritis

被引：8

作者：

Liew, FY ^{[1
]}

McInnes, IB

机构：

[1] Univ Glasgow, Div Immunol Infect & Inflammat, Glasgow G11 6NT, Lanark, Scotland

[2] Univ Glasgow, Ctr Rheumat Dis, Glasgow G11 6NT, Lanark, Scotland

来源：

NATURE MEDICINE | 2005年 / 11卷 / 06期

关键词：

D O I：

10.1038/nm0605-601

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neutrophils persist in the joints of individuals with inflammatory arthritis, where they contribute to disease. The molecular basis of this persistence is now shown to hinge on the forkhead transcription factor Foxo3a. Foxo3a suppresses expression of Fas ligand, preventing neutrophil apoptosis ( pages 666 - 671).

引用

页码：601 / 602

页数：2

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