Illuminating HDL - Is it still a viable therapeutic target?

被引:102
作者
Rader, Daniel J. [1 ]
机构
[1] Univ Penn, Sch Med, Philadelphia, PA 19104 USA
关键词
D O I
10.1056/NEJMe0707210
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
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页码:2180 / 2183
页数:4
相关论文
共 11 条
[1]   Effects of torcetrapib in patients at high risk for coronary events [J].
Barter, Philip J. ;
Caulfield, Mark ;
Eriksson, Mats ;
Grundy, Scott M. ;
Kastelein, John J. P. ;
Komajda, Michel ;
Lopez-Sendon, Jose ;
Mosca, Lori ;
Tardif, Jean-Claude ;
Waters, David D. ;
Shear, Charles L. ;
Revkin, James H. ;
Buhr, Kevin A. ;
Fisher, Marian R. ;
Tall, Alan R. ;
Brewer, Bryan .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (21) :2109-2122
[2]   Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion [J].
Brousseau, ME ;
Diffenderfer, MR ;
Millar, JS ;
Nartsupha, C ;
Asztalos, BF ;
Welty, FK ;
Wolfe, ML ;
Rudling, M ;
Björkhem, I ;
Angelin, B ;
Mancuso, JP ;
Digenio, AG ;
Rader, DJ ;
Schaefer, EJ .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (05) :1057-1064
[3]   Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia [J].
Kastelein, John J. P. ;
van Leuven, Sander I. ;
Burgess, Leslie ;
Evans, Greg W. ;
Kuivenhoven, Jan A. ;
Barter, Philip J. ;
Revkin, James H. ;
Grobbee, Diederick E. ;
Riley, Ward A. ;
Shear, Charles L. ;
Duggan, William T. ;
Bots, Michiel L. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (16) :1620-1630
[4]   Aldosterone and end-organ damage [J].
Marney, Annis M. ;
Brown, Nancy J. .
CLINICAL SCIENCE, 2007, 113 (5-6) :267-278
[5]  
Nissen SE, 2007, NEW ENGL J MED, V357, P835
[6]   Effect of torcetrapib on the progression of coronary atherosclerosis [J].
Nissen, Steven E. ;
Tardif, Jean-Claude ;
Nicholls, Stephen J. ;
Revkin, James H. ;
Shear, Charles L. ;
Duggan, William T. ;
Ruzyllo, Witold ;
Bachinsky, William B. ;
Lasala, Gregory P. ;
Tuzcu, E. Murat .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (13) :1304-1316
[7]   Molecular regulation of HDL metabolism and function: implications for novel therapies [J].
Rader, Daniel J. .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (12) :3090-3100
[8]   Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes [J].
Shiflett, AM ;
Bishop, JR ;
Pahwa, A ;
Hajduk, SL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (38) :32578-32585
[9]   Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport [J].
Tanigawa, Hiroyuki ;
Billheimer, Jeffrey T. ;
Tohyama, Jun-Ichiro ;
Zhang, YuZhen ;
Rothblat, George ;
Rader, Daniel J. .
CIRCULATION, 2007, 116 (11) :1267-1273
[10]   Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL [J].
Vaisar, Tomas ;
Pennathur, Subramaniam ;
Green, Pattie S. ;
Gharib, Sina A. ;
Hoofnagle, Andrew N. ;
Cheung, Marian C. ;
Byun, Jaeman ;
Vuletic, Simona ;
Kassim, Sean ;
Singh, Pragya ;
Chea, Helen ;
Knopp, Robert H. ;
Brunzell, John ;
Geary, Randolph ;
Chait, Alan ;
Zhao, Xue-Qiao ;
Elkon, Keith ;
Marcovina, Santica ;
Ridker, Paul ;
Oram, John F. ;
Heinecke, Jay W. .
JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (03) :746-756