Molecular regulation of HDL metabolism and function: implications for novel therapies

被引：448

作者：

Rader, Daniel J.

机构：

[1] Univ Penn, Med Ctr, Sch Med, Inst Translat Med & Therapeut,Cardiovasc Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 12期

关键词：

D O I：

10.1172/JCI30163

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our under standing of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics.

引用

页码：3090 / 3100

页数：11

共 124 条

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