Molecular regulation of HDL metabolism and function: implications for novel therapies

被引：448

作者：

Rader, Daniel J.

机构：

[1] Univ Penn, Med Ctr, Sch Med, Inst Translat Med & Therapeut,Cardiovasc Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 12期

关键词：

D O I：

10.1172/JCI30163

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our under standing of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics.

引用

页码：3090 / 3100

页数：11

共 124 条

[71] Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and β [J].

Li, AC ;

Binder, CJ ;

Gutierrez, A ;

Brown, KK ;

Plotkin, CR ;

Pattison, JW ;

Valledor, AF ;

Davis, RA ;

Willson, TM ;

Witztum, JL ;

Palinski, W ;

Glass, CK .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (11) :1564-1576

[72] Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism [J].

Ma, K ;

Cilingiroglu, M ;

Otvos, JD ;

Ballantyne, CM ;

Marian, AJ ;

Chan, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) :2748-2753

[73] Putting cholesterol in its place: apoE and reverse cholesterol transport [J].

Mahley, RW ;

Huang, YD ;

Weisgraber, KH .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (05) :1226-1229

[74] Ectopic β-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis [J].

Martinez, LO ;

Jacquet, S ;

Esteve, JP ;

Rolland, C ;

Cabezón, E ;

Champagne, E ;

Pineau, T ;

Georgeaud, V ;

Walker, JE ;

Tercé, F ;

Collet, X ;

Perret, B ;

Barbaras, R .

NATURE, 2003, 421 (6918) :75-79

[75] HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway [J].

Matsuura, F ;

Wang, N ;

Chen, WG ;

Jiang, XC ;

Tall, AR .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (05) :1435-1442

[76] Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase [J].

Maugeais, C ;

Tietge, UJF ;

Broedl, UC ;

Marchadier, D ;

Cain, W ;

McCoy, MG ;

Lund-Katz, S ;

Glick, JM ;

Rader, DJ .

CIRCULATION, 2003, 108 (17) :2121-2126

[77] High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1 [J].

McNeish, J ;

Aiello, RJ ;

Guyot, D ;

Turi, T ;

Gabel, C ;

Aldinger, C ;

Hoppe, KL ;

Roach, ML ;

Royer, LJ ;

de Wet, J ;

Broccardo, C ;

Chimini, G ;

Francone, OL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :4245-4250

[78] Niacin therapy in atherosclerosis [J].

Meyers, CD ;

Kamanna, VS ;

Kashyap, ML .

CURRENT OPINION IN LIPIDOLOGY, 2004, 15 (06) :659-665

[79]

MILLER GJ, 1975, LANCET, V1, P16

[80] Endothelial and antithrombotic actions of HDL [J].

Mineo, Chieko ;

Deguchi, Hiroshi ;

Griffin, John H. ;

Shaul, Philip W. .

CIRCULATION RESEARCH, 2006, 98 (11) :1352-1364

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