Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

被引：127

作者：

Koh, Young Jun ^{[1
,2
]}

Kim, Hak-Zoo ^{[1
,2
]}

Hwang, Seong-Ik ^{[1
,3
]}

Lee, Jeung Eun ^{[1
,3
]}

Oh, Nuri ^{[1
,3
]}

Jung, Keehoon ^{[1
,2
]}

Kim, Minah ^{[1
,3
]}

Kim, Kyung Eun ^{[1
,2
]}

Kim, Homin ^{[3
]}

Lim, Nam-Kyu ^{[5
]}

Jeon, Choon-Ju ^{[5
]}

Lee, Gyun Min ^{[3
,4
]}

Jeon, Byeong Hwa ^{[6
]}

Nam, Do-Hyun ^{[7
]}

Sung, Hoon Ki ^{[8
]}

Nagy, Andras ^{[8
]}

Yoo, Ook Joon ^{[2
]}

Koh, Gou Young ^{[1
,2
,3
,4
,7
]}

机构：

[1] Korea Adv Inst Sci & Technol, Natl Res Lab Vasc Biol & Stem Cells, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Grad Sch Biomed Sci & Engn, Taejon 305701, South Korea

[3] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

[4] Korea Adv Inst Sci & Technol, Grad Sch Nanosci & Technol, Taejon 305701, South Korea

[5] Aprogen Inc, Taejon 305701, South Korea

[6] Chungnam Natl Univ, Sch Med, Dept Physiol, Taejon 301131, South Korea

[7] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Inst Refractory Canc Res Program, Seoul 135710, South Korea

[8] Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Dept Mol Genet, Toronto, ON M5G 1X5, Canada

来源：

CANCER CELL | 2010年 / 18卷 / 02期

关键词：

GROWTH-FACTOR-TRAP; SIGNAL-TRANSDUCTION; DOMAIN; BEVACIZUMAB; INHIBITION; RESISTANCE; REGRESSION; ANTIBODY; ASCITES; BINDING;

D O I：

10.1016/j.ccr.2010.07.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage.

引用

页码：171 / 184

页数：14