Chemo-enzymatic synthesis of calcitonin derivatives containing N-linked oligosaccharides

被引:64
作者
Haneda, K
Inazu, T
Mizuno, M
Iguchi, R
Yamamoto, K
Kumagai, H
Aimoto, S
Suzuki, H
Noda, T
机构
[1] Noguchi Inst, Tokyo 173, Japan
[2] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Sakyo Ku, Kyoto 60601, Japan
[3] Osaka Univ, Inst Prot Res, Suita, Osaka 565, Japan
[4] Asahi Chem Ind Co Ltd, Life Sci Res Inst, Shizuoka 41023, Japan
关键词
glycopeptides; enzyme and enzyme reactions; hormones; glycosylation;
D O I
10.1016/S0960-894X(98)00209-1
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Eel calcitonin derivatives containing various N-linked oligosaccharides were chemo-enzymatically synthesized by the transglycosylation reaction of Mucor hiemalis endo-beta-N-acetylglucosaminidase (Endo-M) to a glycosylated calcitonin derivative [Asn(GlcNAc)(3)]-CT in which N-acetyl-D-glucosamine (GlcNAc) is attached to the L-asparagine (Asn) residue of the peptide. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1303 / 1306
页数:4
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