Chemo-enzymatic synthesis of calcitonin derivatives containing N-linked oligosaccharides

被引：64

作者：

Haneda, K

Inazu, T

Mizuno, M

Iguchi, R

Yamamoto, K

Kumagai, H

Aimoto, S

Suzuki, H

Noda, T

机构：

[1] Noguchi Inst, Tokyo 173, Japan

[2] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Sakyo Ku, Kyoto 60601, Japan

[3] Osaka Univ, Inst Prot Res, Suita, Osaka 565, Japan

[4] Asahi Chem Ind Co Ltd, Life Sci Res Inst, Shizuoka 41023, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 11期

关键词：

glycopeptides; enzyme and enzyme reactions; hormones; glycosylation;

D O I：

10.1016/S0960-894X(98)00209-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eel calcitonin derivatives containing various N-linked oligosaccharides were chemo-enzymatically synthesized by the transglycosylation reaction of Mucor hiemalis endo-beta-N-acetylglucosaminidase (Endo-M) to a glycosylated calcitonin derivative [Asn(GlcNAc)(3)]-CT in which N-acetyl-D-glucosamine (GlcNAc) is attached to the L-asparagine (Asn) residue of the peptide. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1303 / 1306

页数：4

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