Tuning the pH-triggered self-assembly of dendritic peptide amphiphiles using fluorinated side chains

被引：32

作者：

Appel, Ralph ^{[1
,2
]}

Tacke, Sebastian ^{[3
]}

Klingauf, Juergen ^{[3
]}

Besenius, Pol ^{[1
,2
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

[2] Ctr Nanotechnol CeNTech, D-48149 Munster, Germany

[3] Univ Munster, Inst Med Phys & Biophys, Dept Cellular Biophys, D-48149 Munster, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 04期

关键词：

AMINO-ACIDS; SUPRAMOLECULAR POLYMER; DISCOTIC AMPHIPHILES; GOLD NANOPARTICLES; DESIGN; GROWTH; VIRUS; WATER; HYDROGELATORS; AGGREGATION;

D O I：

10.1039/c4ob02185a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the synthesis of a series of anionic dendritic peptide amphiphiles of increasing hydrophobic character. By establishing state diagrams we describe their pH and ionic strength triggered self-assembly into supramolecular nanorods in water and highlight the impact of hydrophobic shielding in the supramolecular polymerisation process. Via the incorporation of fluorinated peptide side chains the pH-triggered monomer to polymer transition at physiological ionic strength is shifted from pH 5.0 to pH 7.4. We thereby show that compensating attractive non-covalent interactions and hydrophobic effects with repulsive electrostatic forces, a concept we refer to as frustrated growth, is a sensitive tool in order to manipulate one-dimensional supramolecular polymerisation processes in water.

引用

页码：1030 / 1039

页数：10

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