A Fast pH-Switchable and Self-Healing Supramolecular Hydrogel Carrier for Guided, Local Catheter Injection in the Infarcted Myocardium

被引：250

作者：

Bastings, Maartje M. C. ^{[1
,2
]}

Koudstaal, Stefan ^{[3
,4
]}

Kieltyka, Roxanne E. ^{[1
,2
]}

Nakano, Yoko ^{[1
,2
]}

Pape, A. C. H. ^{[1
,2
]}

Feyen, Dries A. M. ^{[3
]}

van Slochteren, Frebus J. ^{[3
]}

Doevendans, Pieter A. ^{[3
,4
]}

Sluijter, Joost P. G. ^{[3
,4
]}

Meijer, E. W. ^{[1
,2
,5
]}

Chamuleau, Steven A. J. ^{[3
,4
]}

Dankers, Patricia Y. W. ^{[1
,2
]}

机构：

[1] Eindhoven Univ Technol, Inst Complex Mol Syst, NL-5600 MB Eindhoven, Netherlands

[2] Eindhoven Univ Technol, Biol Chem Lab, NL-5600 MB Eindhoven, Netherlands

[3] Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, NL-3508 GA Utrecht, Netherlands

[4] ICIN, NL-3501 DG Utrecht, Netherlands

[5] Eindhoven Univ Technol, Lab Macromol & Organ Chem, NL-5600 MB Eindhoven, Netherlands

来源：

ADVANCED HEALTHCARE MATERIALS | 2014年 / 3卷 / 01期

基金：

欧洲研究理事会;

关键词：

catheter injection; drug delivery; myocardial infarction; pH-responsive hydrogel; supramolecular polymers; LEFT-VENTRICULAR FUNCTION; GROWTH-FACTOR; STEM-CELLS; MONONUCLEAR-CELLS; CARDIAC-FUNCTION; IN-VITRO; HEART; DELIVERY; SCAFFOLDS; CARDIOMYOCYTES;

D O I：

10.1002/adhm.201300076

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Minimally invasive intervention strategies after myocardial infarction use state-of-the-art catheter systems that are able to combine mapping of the infarcted area with precise, local injection of drugs. To this end, catheter delivery of drugs that are not immediately pumped out of the heart is still challenging, and requires a carrier matrix that in the solution state can be injected through a long catheter, and instantaneously gelates at the site of injection. To address this unmet need, a pH-switchable supramolecular hydrogel is developed. The supramolecular hydrogel is switched into a liquid at pH > 8.5, with a viscosity low enough to enable passage through a 1-m long catheter while rapidly forming a hydrogel in contact with tissue. The hydrogel has self-healing properties taking care of adjustment to the injection site. Growth factors are delivered from the hydrogel thereby clearly showing a reduction of infarct scar in a pig myocardial infarction model.

引用

页码：70 / 78

页数：9

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