Cystothiazoles C-F, new bithiazole-type antibiotics from the myxobacterium Cystobacter fuscus

被引：77

作者：

Suzuki, Y ^{[1
]}

Ojika, M ^{[1
]}

Sakagami, Y ^{[1
]}

Fudou, R ^{[1
]}

Yamanaka, S ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan

来源：

TETRAHEDRON | 1998年 / 54卷 / 38期

关键词：

D O I：

10.1016/S0040-4020(98)00694-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bithiazole-type antifungal products, cystothiazoles C-F (3-6), have been isolated from a culture broth of the myxobacterium Cystobacter fuscus as minor components. These are structurally related to cystothiazole A (1), which was isolated as a cytotoxic antibiotic from the same microorganism in our previous work. The structures of these compounds were elucidated by spectroscopic analyses. These new compounds inhibit the phytopathogenic fungus, Phytophthora capsici, but are less active than 1. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：11399 / 11404

页数：6

共 6 条

[1] MYXOTHIAZOL, AN ANTIBIOTIC FROM MYXOCOCCUS-FULVUS (MYXOBACTERALES) .1. CULTIVATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES [J].

GERTH, K ;

IRSCHIK, H ;

REICHENBACH, H ;

TROWITZSCH, W .

JOURNAL OF ANTIBIOTICS, 1980, 33 (12) :1474-1479

[2]

HOFLE G, 1995, Patent No. 4410449

[3] Cystothiazoles A and B, new bithiazole-type antibiotics from the myxobacterium Cystobacter fuscus [J].

Ojika, M ;

Suzuki, Y ;

Tsukamoto, A ;

Sakagami, Y ;

Fudou, R ;

Yoshimura, T ;

Yamanaka, S .

JOURNAL OF ANTIBIOTICS, 1998, 51 (03) :275-281

[4] MYXOTHIAZOL, A NEW INHIBITOR OF THE CYTOCHROME B-C1 SEGMENT OF THE RESPIRATORY-CHAIN [J].

THIERBACH, G ;

REICHENBACH, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 638 (02) :282-289

[5]

VONJAGOW G, 1984, J BIOL CHEM, V259, P6318

[6] Epothilones: Promising natural products with taxol-like activity [J].

Wessjohann, L .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (07) :715-718

← 1 →