Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral α-glucosidase inhibitory activity as antitumour agents

被引：77

作者：

Sanchez-Fernandez, Elena M. ^{[2
]}

Risquez-Cuadro, Rocio ^{[1
]}

Chasseraud, Maud ^{[3
]}

Ahidouch, Ahmed ^{[3
]}

Ortiz Mellet, Carmen ^{[1
]}

Ouadid-Ahidouch, Halima ^{[3
]}

Garcia Fernandez, Jose M. ^{[2
]}

机构：

[1] Univ Seville, Fac Quim, Dept Quim Organ, E-41071 Seville, Spain

[2] CSIC, Inst Invest Quim, E-41092 Seville, Spain

[3] Fac Sci, JE Canaux Ion Canc Sein 2530, Lab Physiol Cellulaire & Mol, Amiens, France

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 29期

关键词：

TYPE-2; DIABETES-MELLITUS; IMINOSUGARS; MIMICS; CANCER;

D O I：

10.1039/c0cc00446d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

sp(2)-Iminosugar-type castanospermine analogues bearing an alpha-configured N-, S-, or C-linked pseudoanomeric group have been designed as selective inhibitors of the neutral alpha-glucosidases involved in N- glycoprotein processing; evaluation in breast cancer cell growth indicated a significant antiproliferative potential that was dependent on the nature of the pseudoanomeric group.

引用

页码：5328 / 5330

页数：3

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