Bone-strengthening supplement (BSP) promotes bone and cartilage repair, for the treatment of Osteonecrosis of Femoral Head: an MRI-based study

被引：9

作者：

Li, Zheng ^{[1
]}

Wei, Jin ^{[2
]}

Xiao, Hong ^{[3
]}

Zhu, Liguo ^{[4
]}

Weng, Xisheng ^{[1
]}

Jin, Jin ^{[1
]}

Zhang, Jun ^{[4
]}

Wang, Heming ^{[5
]}

Ge, Jirong ^{[5
]}

Tao, Tianzun ^{[6
]}

Pei, Lingpeng ^{[7
]}

Dong, Xin ^{[8
]}

Wang, Lulin ^{[3
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing 100730, Peoples R China

[2] Capital Med Univ, Dept Dermatol & Venereol, Affiliated Beijing Ditan Hosp, Beijing 100015, Peoples R China

[3] Beijing Jianxing Tradit Chinese Med Hosp, Dept Orthoped, Beijing 100007, Peoples R China

[4] China Acad Chinese Med Sci, Wangjing Hosp, Beijing 100102, Peoples R China

[5] Fujian Prov Inst Tradit Chinese Med, Fuzhou 350003, Fujian, Peoples R China

[6] Harbin Med Univ, Affiliated Hosp 2, Dept Orthoped, Harbin 150001, Heilongjiang, Peoples R China

[7] Univ MINZU, Tradit Chinese Med, Beijing 100081, Peoples R China

[8] Beijing Zhongguancun Hosp, Dept Radiol, Beijing 100190, Peoples R China

来源：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2019年 / 11卷 / 12期

关键词：

Bone and joint disease; osteonecrosis of the femoral head; bone-strengthening supplement; BSP; MRI; TOTAL HIP-ARTHROPLASTY; CORE DECOMPRESSION; NECROSIS; PILL; CELL;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Currently, no effective drug treatment is available for bone and joint disease, a disorder of the bone and cartilage cells. Osteonecrosis of the femoral head (ONFH) is an example of bone and joint disease. It is progressive, with femoral head collapse resulting from the death of osteocytes and the bone marrow, leading to a poor quality of life and surgical interventions. However, the mechanism of this disease is still unknown, and the effects of current therapy are not satisfactory. In our previous study, we showed, using an ONFH rat model, that a new Chinese medicine, "bone-strengthening supplement" (BSP), enhances bone growth, promotes bone density, and restores blood circulation in the femoral head, and can significantly relieve pain, improve hip joint function, and reduce claudication. In the present study, we evaluated the curative effect of BSP in patients with ONFH using MRI with a double-blind randomized protocol. BSP significantly relieved pain unlike the control treatment; in addition, this treatment could improve MRI signal in ONFH patients. These results suggest that, overall; BSP can restore blood circulation and promote bone and cartilage growth during restoration of bone necrosis and the treatment of bone and joint disease.

引用

页码：7449 / 7455

页数：7

共 35 条

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