Parallel synthesis of 1,2,4-oxadiazoles from carboxylic acids using an improved, uronium-based, activation

被引：82

作者：

Poulain, RF

Tartar, AL

Déprez, BP

机构：

[1] Fac Sci & Pharmaceut & Biol, Chim Organ Lab, UMR 8525, F-59006 Lille, France

[2] Devgen nv, B-9052 Ghent, Belgium

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(00)02293-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the synthesis of 1,2,4-oxadiazoles from carboxylic acids and amidoximes using 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) as an activating agent of the carboxylic acid function for the O-acylation step. This method was used for the synthesis of a library of 24 1,2,4-oxadiazoles. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1495 / 1498

页数：4

共 14 条

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