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Combinatorial transcription factors

被引：46
作者：
Wolberger, C [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0959-437X(98)80010-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern assembly of these complexes. Three-dimensional structures have been determined of the MAT alpha 2/MCM1-DNA complex, the p50/p65 Rel homology domain heterodimer bound to DNA, the NFAT/Fos-Jun/DNA quaternary complex, and of the GABP alpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA.
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页码：552 / 559
页数：8
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