A new route to acyclic nucleosides via palladium-mediated allylic alkylation and cross-metathesis

被引：26

作者：

Amblard, F

Nolan, SP

Gillaizeau, I

Agrofoglio, LA ^{[1
]}

机构：

[1] Univ Orleans, CNRS, UMR 6005, Inst Chim Organ & Analyt, F-45067 Orleans, France

[2] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 51期

关键词：

palladium-mediated allylic alkylation; cross-metathesis; acyclonucleosides;

D O I：

10.1016/j.tetlet.2003.10.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the syntheses of E-unsaturated acyclic nucleosides via a combination of palladium-catalyzed allylic alkylation and ruthenium-based cross metathesis is described. This approach provides a concise, efficient and reliable route to new nucleoside analogues. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：9177 / 9180

页数：4

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