A new route to acyclic nucleosides via palladium-mediated allylic alkylation and cross-metathesis

被引:26
作者
Amblard, F
Nolan, SP
Gillaizeau, I
Agrofoglio, LA [1 ]
机构
[1] Univ Orleans, CNRS, UMR 6005, Inst Chim Organ & Analyt, F-45067 Orleans, France
[2] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA
关键词
palladium-mediated allylic alkylation; cross-metathesis; acyclonucleosides;
D O I
10.1016/j.tetlet.2003.10.029
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A method for the syntheses of E-unsaturated acyclic nucleosides via a combination of palladium-catalyzed allylic alkylation and ruthenium-based cross metathesis is described. This approach provides a concise, efficient and reliable route to new nucleoside analogues. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:9177 / 9180
页数:4
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