The origin of CDK regulation

被引：46

作者：

Li, A ^{[1
]}

Blow, JJ ^{[1
]}

机构：

[1] Univ Dundee, Wellcome Trust Bioctr, CRC, Chromsome Replicat Res Grp, Dundee DD1 5EH, Scotland

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 08期

关键词：

D O I：

10.1038/35087119

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cip/Kip proteins that inhibit cyclin dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and subsequent initiation of replication is co-ordinately regulated at, and localized to, replication origins.

引用

页码：E182 / E184

页数：3

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