The basic chemistry of nitrogen monoxide and peroxynitrite

被引：285

作者：

Koppenol, WH ^{[1
]}

机构：

[1] ETH Zurich, Anorgan Chem Lab, CH-8092 Zurich, Switzerland

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1998年 / 25卷 / 4-5期

关键词：

nitrogen monoxide; peroxynitrite; kinetics; thermodynamics; reduction potential; superoxide dismutase; review;

D O I：

10.1016/S0891-5849(98)00093-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

After a discussion of the physical chemistry of nitrogen monoxide, such as solubility (1.55 mM at 37 degrees C and an ionic strength of 0.15 M) and diffusion constant (4.8 x 10(-5) cm(2)s(-1)), several reactions that can acts as sinks are discussed, namely the reaction with dioxygen, with thiols and with superoxide. Of these, the latter reaction leads to a powerful oxidant, peroxynitrite. The thermodynamic and kinetic properties of this molecule are also reviewed. (C) 1998 Elsevier Science Inc.

引用

页码：385 / 391

页数：7

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