The role of focal-adhesion kinase in cancer. A ew therapeutic opportunity

被引：871

作者：

McLean, GW ^{[1
]}

Carragher, NO ^{[1
]}

Avizienyte, E ^{[1
]}

Evans, J ^{[1
]}

Brunton, VG ^{[1
]}

Frame, MC ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Canc Res UK Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 07期

关键词：

D O I：

10.1038/nrc1647

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Focal- adhesion kinase ( FAK) is an important mediator of growth- factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.

引用

页码：505 / 515

页数：11

共 128 条

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