The role of focal-adhesion kinase in cancer. A ew therapeutic opportunity

被引：877

作者：

McLean, GW ^{[1
]}

Carragher, NO ^{[1
]}

Avizienyte, E ^{[1
]}

Evans, J ^{[1
]}

Brunton, VG ^{[1
]}

Frame, MC ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Canc Res UK Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 07期

关键词：

D O I：

10.1038/nrc1647

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Focal- adhesion kinase ( FAK) is an important mediator of growth- factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.

引用

页码：505 / 515

页数：11

共 128 条

[41] Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation [J].

Glading, A ;

Bodnar, RJ ;

Reynolds, IJ ;

Shiraha, H ;

Satish, L ;

Potter, DA ;

Blair, HC ;

Wells, A .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (06) :2499-2512

[42] Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites [J].

Golubovskaya, V ;

Kaur, A ;

Cance, W .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2004, 1678 (2-3) :111-125

[43] Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells [J].

Golubovskaya, V ;

Beviglia, L ;

Xu, LH ;

Earp, HS ;

Craven, R ;

Cance, W .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (41) :38978-38987

[44]

Golubovskaya VM, 2003, MOL CANCER RES, V1, P755

[45] Differential expression of protease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples [J].

Grisaru-Granovsky, S ;

Salah, Z ;

Maoz, M ;

Pruss, D ;

Beller, U ;

Bar-Shavit, R .

INTERNATIONAL JOURNAL OF CANCER, 2005, 113 (03) :372-378

[46] Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility [J].

Hanks, SK ;

Ryzhova, L ;

Shin, NY ;

Brábek, J .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2003, 8 :D982-D996

[47]

Haskell H, 2003, CLIN CANCER RES, V9, P2157

[48] FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth [J].

Hauck, CR ;

Hsia, DA ;

Puente, XS ;

Cheresh, DA ;

Schlaepfer, DD .

EMBO JOURNAL, 2002, 21 (23) :6289-6302

[49] v-Src SH3-enhanced interaction with focal adhesion kinase at β1 integrin-containing invadopodia promotes cell invasion [J].

Hauck, CR ;

Hsia, DA ;

Ilic, D ;

Schlaepfer, DD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (15) :12487-12490

[50] Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells [J].

Hecker, TP ;

Ding, Q ;

Rege, TA ;

Hanks, SK ;

Gladson, CL .

ONCOGENE, 2004, 23 (22) :3962-3971

← 1 2 3 4 5 6 7 8 9 10 →