Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon

被引：83

作者：

Wright, Amanda G. ^{[1
,2
]}

Demyanenko, Galina P. ^{[1
,2
]}

Powell, Ashton ^{[2
]}

Schachner, Melitta ^{[3
,4
,5
]}

Enriquez-Barreto, Lilian ^{[1
,2
,7
]}

Tran, Tracy S. ^{[6
]}

Polleux, Franck ^{[2
]}

Maness, Patricia F. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Biochem, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, Neurosci Res Ctr, Chapel Hill, NC 27599 USA

[3] Univ Hamburg, D-20246 Hamburg, Germany

[4] Rutgers State Univ, Dept Anat Cell Biol & Neurosci, Keck Ctr Collaborat Neurosci, Piscataway, NJ 08854 USA

[5] Dalian Med Univ, Sino German Ctr Neurosci, Dalian 116011, Liaoning, Peoples R China

[6] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Neurosci, Baltimore, MD 21218 USA

[7] Inst Neurosci Alicante, Alicante 03550, Spain

来源：

JOURNAL OF NEUROSCIENCE | 2007年 / 27卷 / 50期

关键词：

thalamocortical; axon guidance; cell adhesion molecule; semaphorin; neuropilin; somatosensory;

D O I：

10.1523/JNEUROSCI.2888-07.2007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report a cooperation between the neural adhesion molecule close homolog of L1 (CHL1) and the semaphorin 3A (Sema3A) receptor, neuropilin 1 (Npn1), important for establishment of area-specific thalamocortical projections. CHL1 deletion in mice selectively disrupted the projection of somatosensory thalamic axons from the ventrobasal (VB) nuclei, causing them to shift caudally and target the visual cortex. At the ventral telencephalon, an intermediate target with graded Sema3A expression, VB axons were caudally shifted in CHL1(-) embryos and in Npn1Sema(-/-) mutants, in which axons are nonresponsive to Sema3A. CHL1 colocalized with Npn1 on thalamic axons, and associated with Npn1 through a sequence in the CHL1 Ig1 domain that was required for Sema3A- induced growth cone collapse. These results identify a novel function for CHL1 in thalamic axon responsiveness to ventral telencephalic cues, and demonstrate a role for CHL1 and Npn1 in establishment of proper targeting of specific thalamocortical projections.

引用

页码：13667 / 13679

页数：13

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