Unique functions of the type 11 interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain

被引：153

作者：

Ramalingam, Thirumalai R. ^{[1
]}

Pescel, John T. ^{[1
]}

Sheikh, Faruk ^{[2
]}

Cheever, Allen W. ^{[3
]}

Mentink-Kane, Margaret M. ^{[1
]}

Wilson, Mark S. ^{[1
]}

Stevens, Sean ^{[4
]}

Valenzuela, David M. ^{[4
]}

Murphy, Andrew J. ^{[4
]}

Yancopoulos, George D. ^{[4
]}

Urban, Joseph F., Jr. ^{[5
]}

Donnelly, Raymond P. ^{[2
]}

Wynn, Thomas A. ^{[1
]}

机构：

[1] NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA

[2] US FDA, Ctr Drug Evaluat & Res, Div Therapeut Prot, Bethesda, MD 20892 USA

[3] Inst Biomed Res, Rockville, MD 20892 USA

[4] Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA

[5] USDA, BHNRC, Diet Genom & Immunol Lab, Beltsville, MD 20705 USA

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 01期

关键词：

D O I：

10.1038/ni1544

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interleukin 4 receptor (IL-4R) is a central mediator of T helper type 2 (T(H)2)-mediated disease and associates with either the common gamma-chain to form the type I IL-4R or with the IL-13R alpha 1 chain (IL-13R alpha 1) to form the type II IL-4R. Here we used II13ral(-/-) mice to characterize the distinct functions of type I and type II IL-4 receptors in vivo. In contrast to II4ra(-/-) mice, which have weak T(H)2 responses, II13ra1(-/-) mice had exacerbated T(H)2 responses. II13ra1(-/-) mice showed much less mortality after infection with Schistosoma mansoni and much more susceptibility to Nippostrongylus brasiliensis. IL-13R alpha 1 was essential for allergen-induced airway hyperreactivity and mucus hypersecretion but not for fibroblast or alternative macrophage activation. Thus, type I and II IL-4 receptors exert distinct effects on immune responses.

引用

页码：25 / 33

页数：9

共 53 条

[1]

Adams NC, 2006, PRIN PRACT, P131

[2] Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites [J].

Anthony, Robert M. ;

Urban, Joseph F., Jr. ;

Alem, Farhang ;

Hamed, Hossein A. ;

Rozo, Cristina T. ;

Boucher, Jean-Luc ;

Van Rooijen, Nico ;

Gause, William C. .

NATURE MEDICINE, 2006, 12 (08) :955-960

[3]

Brunet LR, 1997, J IMMUNOL, V159, P777

[4] An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response [J].

Chiaramonte, MG ;

Donaldson, DD ;

Cheever, AW ;

Wynn, TA .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (06) :777-785

[5] Regulation and function of the interleukin 13 receptor α 2 during a T helper cell type 2-dominant immune response [J].

Chiaramonte, MG ;

Mentink-Kane, M ;

Jacobson, BA ;

Cheever, AW ;

Whitters, MJ ;

Goad, MEP ;

Wong, A ;

Collins, M ;

Donaldson, DD ;

Grusby, MJ ;

Wynn, TA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (06) :687-701

[6] IL-13 INDUCES PROLIFERATION AND DIFFERENTIATION OF HUMAN B-CELLS ACTIVATED BY THE CD40-LIGAND [J].

COCKS, BG ;

MALEFYT, RD ;

GALIZZI, JP ;

DEVRIES, JE ;

AVERSA, G .

INTERNATIONAL IMMUNOLOGY, 1993, 5 (06) :657-663

[7] Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression [J].

Dickensheets, HL ;

Venkataraman, C ;

Schindler, U ;

Donnelly, RP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (19) :10800-10805

[8]

Doucet C, 2002, EUR J IMMUNOL, V32, P2437, DOI 10.1002/1521-4141(200209)32:9<2437::AID-IMMU2437>3.0.CO

[9]

2-N

[10] Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13 [J].

Emson, CL ;

Bell, SE ;

Jones, A ;

Wisden, W ;

McKenzie, ANJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (02) :399-404

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