Unique functions of the type 11 interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain

被引：153

作者：

Ramalingam, Thirumalai R. ^{[1
]}

Pescel, John T. ^{[1
]}

Sheikh, Faruk ^{[2
]}

Cheever, Allen W. ^{[3
]}

Mentink-Kane, Margaret M. ^{[1
]}

Wilson, Mark S. ^{[1
]}

Stevens, Sean ^{[4
]}

Valenzuela, David M. ^{[4
]}

Murphy, Andrew J. ^{[4
]}

Yancopoulos, George D. ^{[4
]}

Urban, Joseph F., Jr. ^{[5
]}

Donnelly, Raymond P. ^{[2
]}

Wynn, Thomas A. ^{[1
]}

机构：

[1] NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA

[2] US FDA, Ctr Drug Evaluat & Res, Div Therapeut Prot, Bethesda, MD 20892 USA

[3] Inst Biomed Res, Rockville, MD 20892 USA

[4] Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA

[5] USDA, BHNRC, Diet Genom & Immunol Lab, Beltsville, MD 20705 USA

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 01期

关键词：

D O I：

10.1038/ni1544

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interleukin 4 receptor (IL-4R) is a central mediator of T helper type 2 (T(H)2)-mediated disease and associates with either the common gamma-chain to form the type I IL-4R or with the IL-13R alpha 1 chain (IL-13R alpha 1) to form the type II IL-4R. Here we used II13ral(-/-) mice to characterize the distinct functions of type I and type II IL-4 receptors in vivo. In contrast to II4ra(-/-) mice, which have weak T(H)2 responses, II13ra1(-/-) mice had exacerbated T(H)2 responses. II13ra1(-/-) mice showed much less mortality after infection with Schistosoma mansoni and much more susceptibility to Nippostrongylus brasiliensis. IL-13R alpha 1 was essential for allergen-induced airway hyperreactivity and mucus hypersecretion but not for fibroblast or alternative macrophage activation. Thus, type I and II IL-4 receptors exert distinct effects on immune responses.

引用

页码：25 / 33

页数：9

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