Magnolol: A multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis

被引：34

作者：

Chen, Yung-Hsiang ^{[1
,2
,3
]}

Huang, Po-Hsun ^{[4
,5
]}

Lin, Feng-Yen ^{[6
]}

Chen, Wen-Chi ^{[2
,3
]}

Chen, Yuh-Lien ^{[7
]}

Yin, Wei-Hsian ^{[5
,8
]}

Man, Kee-Ming ^{[1
,9
,10
]}

Liu, Po-Len ^{[11
]}

机构：

[1] Tungs Taichung MetroHarbor Hosp, Dept Anesthesiol, Taichung 435, Taiwan

[2] China Med Univ, Grad Inst Integrated Med, Dept Urol, Taichung, Taiwan

[3] China Med Univ, Grad Inst Integrated Med, Dept Med Res, Taichung, Taiwan

[4] Taipei Vet Gen Hosp, Div Cardiol, Taipei, Taiwan

[5] Natl Yang Ming Univ, Cardiovasc Res Ctr, Dept Med, Taipei 112, Taiwan

[6] Taipei Med Univ, Coll Med, Dept Internal Med, Taipei, Taiwan

[7] Natl Taiwan Univ, Inst Anat & Cell Biol, Taipei 10764, Taiwan

[8] Cheng Hsin Gen Hosp, Ctr Heart, Taipei, Taiwan

[9] Natl Chung Hsing Univ, Dept Life Sci, Taichung 40227, Taiwan

[10] Anhui Med Univ, Grad Inst Geriatr Med, Hefei, Peoples R China

[11] Kaohsiung Med Univ, Coll Med, Dept Resp Therapy, Kaohsiung 80708, Taiwan

来源：

EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE | 2011年 / 3卷 / 04期

关键词：

Antioxidant; Chinese medicine; Inflammation; Integrative medicine; Magnolol; ISCHEMIA-REPERFUSION INJURY; CHOLESTEROL-FED RABBITS; BRONCHIAL-ASTHMA; SAIBOKU-TO; SMOOTH-MUSCLE; IN-VITRO; CELL-PROLIFERATION; INDUCED APOPTOSIS; POLYMORPHONUCLEAR LEUKOCYTES; 5-HYDROXYTRYPTAMINE RELEASE;

D O I：

10.1016/j.eujim.2011.09.002

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Introduction: Chinese herbs are widely used as important remedies in Oriental integrative medicine. Magnolol is a small polyphenolic molecule with low toxicity that is isolated from the herb genus Magnolia. In preclinical experiments, magnolol was found to have anti-oxidative, anti-inflammatory, anti-tumorigenic, anti-diabetic, anti-microbial, anti-neurodegenerative and anti-depressant properties. Magnolol can also effectively regulate pain control, hormonal signalling, gastrointestinal and uterus modulation as well as provide cardiovascular and liver protective effects. Materials and methods: We briefly conducted PubMed and MEDLINE database reviews for articles that related to magnolol. Results: The major biological mechanisms of action and potential health benefits of magnolol are described. Conclusions: These health benefits of magnolol have provided an increased interest in bringing this herbal compound to the clinic as a novel therapeutic agent. Knowledge of the multiple activities of magnolol can assist with the development of magnolol derivatives and the design of clinical trials that will maximize the potential benefit of magnolol in the patient setting. (C) 2011 Published by Elsevier GmbH.Results: The major biological mechanisms of action and potential health benefits of magnolol are described.

引用

页码：E311 / E318

页数：8

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