Antifungal activity of magnolol and honokiol

被引：142

作者：

Bang, KH

Kim, YK

Min, BS

Na, MK

Rhee, YH

Lee, JP

Bae, KH ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Kolon Pharmaceut Inc, R&D Ctr, Taejon 306220, South Korea

[3] Chungnam Natl Univ, Dept Microbiol, Taejon 305764, South Korea

[4] Korea Food & Drug Adm, Nat Med Prod Div, Seoul 122704, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2000年 / 23卷 / 01期

关键词：

magnolol; honokiol; human pathogenic fungi; Magnolia obovata; Magnoliaceae;

D O I：

10.1007/BF02976465

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two neolignan compounds, magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl, 1) and honokiol (5,5'-diallyl-2,4'-dihydroxybiphenyl, 2), were isolated from the stem bark of Magnolia obovata and evaluated for antifungal activity against various human pathogenic fungi. Compound 1 and 2 showed significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 mu g/ml. Therefore, compound 1 and 2 could be used as lead compounds for the development of novel antifungal agents.

引用

页码：46 / 49

页数：4

共 16 条

[1]

BAE K, 1985, Archives of Pharmacal Research (Seoul), V8, P85, DOI 10.1007/BF02912226

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