STRUCTURE OF MAGNOLIANIN, A NOVEL TRILIGNAN POSSESSING POTENT 5-LIPOXYGENASE INHIBITORY ACTIVITY

被引：15

作者：

FUKUYAMA, Y

OTOSHI, Y

MIYOSHI, K

HASEGAWA, N

KAN, Y

KODAMA, M

机构：

[1] Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, 770, Yamashiro-cho

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)77489-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Magnolianin, a novel trilignan with a 1, 4-benzodioxane ring, isolated from the bark of Magnolia obovata, has been assigned structure on the basis of extensive analysis of 2D H-1 and C-13 NMR of its triacetate derivative. Magnolianin has been found to inhibit strongly (IC50 = 0.45 muM) 5-HETE formation by the cytosol of guinea pig polymorphonuclear leukocytes.

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页码：1051 / 1054

页数：4

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