Transcription-coupled mutagenesis by the DNA deaminase AID

被引：26

作者：

Larson, ED

Maizels, N

机构：

[1] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98195 USA

[2] Univ Washington, Sch Med, Dept Biochem, Seattle, WA 98195 USA

来源：

GENOME BIOLOGY | 2004年 / 5卷 / 03期

关键词：

D O I：

10.1186/gb-2004-5-3-211

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA.

引用

页数：3

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