The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro

被引：5

作者：

Cardile, V

Mascarucci, P

DeSimoni, MG

Jiang, XH

Bindoni, M

机构：

[1] UNIV CATANIA,INST HUMAN PHYSIOL,FAC MED,I-95125 CATANIA,ITALY

[2] MARIO NEGRI INST PHARMACOL RES,I-20157 MILAN,ITALY

来源：

CYTOKINE | 1996年 / 8卷 / 09期

关键词：

ether lipid ET-18-OCH3; PAF; CPAF; interleukin; 6; thymic epithelium;

D O I：

10.1006/cyto.1996.0092

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the greatest effect at the dose of 2 mu g/ml. PAF had no effect. The non-metabolizable CPAF was less effective than ET-18-OCH3 and showed the greatest release of IL-6 at the dose of 1 mu g/ml. Ether lipid ET-18-OCH3 has a thymotrophic effect as has also been demonstrated by other results obtained in our previous work. (C) 1996 Academic Press Limited

引用

页码：698 / 701

页数：4

共 17 条

[1] EFFECTS OF GROWTH-FACTORS ON CYTOKINE PRODUCTION IN SERUM-FREE CULTURES OF HUMAN THYMIC EPITHELIAL-CELLS [J].