Screening for Lipid Disorders in Children and Adolescents US Preventive Services Task Force Recommendation Statement

被引：144

作者：

Bibbins-Domingo, Kirsten ^{[1
]}

Grossman, David C. ^{[2
]}

Curry, Susan J. ^{[3
]}

Davidson, Karina W. ^{[4
]}

Epling, John W., Jr. ^{[5
]}

Garcia, Francisco A. R. ^{[6
]}

Gillman, Matthew W. ^{[7
,8
]}

Kemper, Alex R. ^{[9
]}

Krist, Alex H. ^{[10
,11
]}

Kurth, Ann E. ^{[12
]}

Landefeld, C. Seth ^{[13
]}

LeFevre, Michael ^{[14
]}

Mangione, Carol M. ^{[15
]}

Phillips, William R. ^{[16
]}

Phipps, Maureen G. ^{[17
]}

Pignone, Michael P. ^{[18
]}

Siu, Albert L. ^{[19
,20
]}

机构：

[1] Univ Calif San Francisco, San Francisco, CA 94143 USA

[2] Grp Hlth Res Inst, Seattle, WA USA

[3] Univ Iowa, Iowa City, IA USA

[4] Columbia Univ, New York, NY USA

[5] SUNY Upstate Med Univ, Syracuse, NY 13210 USA

[6] Pima Cty Dept Hlth, Tucson, AZ USA

[7] Harvard Med Sch, Boston, MA USA

[8] Harvard Pilgrim Hlth Care Inst, Boston, MA USA

[9] Duke Univ, Durham, NC USA

[10] Fairfax Family Practice Residency, Fairfax, VA USA

[11] Virginia Commonwealth Univ, Richmond, VA 23284 USA

[12] Yale Univ, New Haven, CT USA

[13] Univ Alabama Birmingham, Birmingham, AL USA

[14] Univ Missouri, Columbia, MO 65211 USA

[15] Univ Calif Los Angeles, Los Angeles, CA USA

[16] Univ Washington, Seattle, WA 98195 USA

[17] Brown Univ, Providence, RI 02912 USA

[18] Univ Texas Austin, Austin, TX 78712 USA

[19] Mt Sinai Sch Med, New York, NY USA

[20] James J Peters Vet Affairs Med Ctr, Bronx, NY USA

来源：

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2016年 / 316卷 / 06期

基金：

美国医疗保健研究与质量局;

关键词：

FAMILIAL HYPERCHOLESTEROLEMIA; DYSLIPIDEMIA; THERAPY; DISEASE; TRENDS; RISK;

D O I：

10.1001/jama.2016.9852

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IMPORTANCE Elevations in levels of total, low-density lipoprotein, and non-high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovascular disease in adults. OBJECTIVE To update the 2007 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in children, adolescents, and young adults. EVIDENCE REVIEW The USPSTF reviewed the evidence on screening for lipid disorders in children and adolescents 20 years or younger-1 review focused on screening for heterozygous familial hypercholesterolemia, and 1 review focused on screening for multifactorial dyslipidemia. FINDINGS Evidence on the quantitative difference in diagnostic yield between universal and selective screening approaches, the effectiveness and harms of long-term treatment and the harms of screening, and the association between changes in intermediate outcomes and improvements in adult cardiovascular health outcomes are limited. Therefore, the USPSTF concludes that the balance of benefits and harms cannot be determined. CONCLUSIONS AND RECOMMENDATION The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for lipid disorders in children and adolescents 20 years or younger. (I statement)

引用

页码：625 / 633

页数：9

共 32 条

[11] Screening and treatment for lipid disorders in children and adolescents: Systematic evidence review for the US preventive services task force [J].

Haney, Elizabeth M. ;

Huffman, Laurie Hoyt ;

Bougatsos, Christina ;

Freeman, Michele ;

Steiner, Robert D. ;

Nelson, Heidi D. .

PEDIATRICS, 2007, 120 (01) :E189-E214

[12] Patterns of Lipid Lowering Therapy among Children Ages 8-20 Years [J].

Joyce, Nina ;

Wellenius, Gregory A. ;

Dore, David D. ;

Newburger, Jane W. ;

Zachariah, Justin P. .

JOURNAL OF PEDIATRICS, 2015, 167 (01) :113-U483

[13]

Kit BK, 2015, JAMA PEDIATR, V169, P272, DOI 10.1001/jamapediatrics.2014.3216

[14] Trends in Serum Lipids Among US Youths Aged 6 to 19 Years, 1988-2010 [J].

Kit, Brian K. ;

Carroll, Margaret D. ;

Lacher, David A. ;

Sorlie, Paul D. ;

DeJesus, Janet M. ;

Ogden, Cynthia L. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 308 (06) :591-600

[15] Ten-Year Follow-up After Initiation of Statin Therapy in Children With Familial Hypercholesterolemia [J].

Kusters, D. Meeike ;

Avis, Hans J. ;

de Groot, Eric ;

Wijburg, Frits A. ;

Kastelein, John J. P. ;

Wiegman, Albert ;

Hutten, Barbara A. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2014, 312 (10) :1055-1057

[16]

LAUER RM, 1992, PEDIATRICS, V89, P495

[17]

Lozano P, JAMA-J AM MED ASSOC, DOI [10.1001/jama.2016.6423, DOI 10.1001/JAMA.2016]

[18]

Lozano P, 2016, AHRQ PUBLICATION, V141

[19] Lipid Screening in Childhood and Adolescence for Detection of Familial Hypercholesterolemia Evidence Report and Systematic Review for the US Preventive Services Task Force [J].

Lozano, Paula ;

Henrikson, Nora B. ;

Dunn, John ;

Morrison, Caitlin C. ;

Nguyen, Matt ;

Blasi, Paula R. ;

Anderson, Melissa L. ;

Whitlock, Evelyn P. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 316 (06) :645-655

[20] Utility of currently recommended pediatric dyslipidemia classifications in predicting dyslipidemia in adulthood - Evidence from the childhood determinants of adult health (CDAH) study, Cardiovascular Risk in Young Finns Study, and Bogalusa Heart Study [J].

Magnussen, Costan G. ;

Raitakari, Olli T. ;

Thomson, Russell ;

Juonala, Markus ;

Patel, Dharmendrakumar A. ;

Viikari, Jorma S. A. ;

Marniemi, Jukka ;

Srinivasan, Sathanur R. ;

Berenson, Gerald S. ;

Dwyer, Terence ;

Venn, Alison .

CIRCULATION, 2008, 117 (01) :32-42

← 1 2 3 4 →