Regulation of hepatic metabolism by AMPK

被引:100
作者
Foretz, Marc [1 ]
Viollet, Benoit [1 ]
机构
[1] Inst Cochin, Dept Endocrinol Metab & Canc, INSERM, U1016, F-75014 Paris, France
关键词
AMP-activated protein kinase; LKB1; Metformin; Energy metabolism; Transcriptional regulation; ACTIVATED PROTEIN-KINASE; PHOSPHORYLATION; MICE;
D O I
10.1016/j.jhep.2010.09.014
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
引用
收藏
页码:827 / 829
页数:3
相关论文
共 10 条
[1]
Resveratrol improves health and survival of mice on a high-calorie diet [J].
Baur, Joseph A. ;
Pearson, Kevin J. ;
Price, Nathan L. ;
Jamieson, Hamish A. ;
Lerin, Carles ;
Kalra, Avash ;
Prabhu, Vinayakumar V. ;
Allard, Joanne S. ;
Lopez-Lluch, Guillermo ;
Lewis, Kaitlyn ;
Pistell, Paul J. ;
Poosala, Suresh ;
Becker, Kevin G. ;
Boss, Olivier ;
Gwinn, Dana ;
Wang, Mingyi ;
Ramaswamy, Sharan ;
Fishbein, Kenneth W. ;
Spencer, Richard G. ;
Lakatta, Edward G. ;
Le Couteur, David ;
Shaw, Reuben J. ;
Navas, Placido ;
Puigserver, Pere ;
Ingram, Donald K. ;
de Cabo, Rafael ;
Sinclair, David A. .
NATURE, 2006, 444 (7117) :337-342
[2]
AMP-activated protein kinase and its downstream transcriptional pathways [J].
Canto, Carles ;
Auwerx, Johan .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2010, 67 (20) :3407-3423
[3]
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome [J].
Cool, Barbara ;
Zinker, Bradley ;
Chiou, William ;
Kifle, Lemma ;
Cao, Ning ;
Perham, Matthew ;
Dickinson, Robert ;
Adler, Andrew ;
Gagne, Gerard ;
Iyengar, Rajesh ;
Zhao, Gang ;
Marsh, Kennan ;
Kym, Philip ;
Jung, Paul ;
Camp, Heidi S. ;
Frevert, Ernst .
CELL METABOLISM, 2006, 3 (06) :403-416
[4]
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver [J].
Foretz, M ;
Ancellin, N ;
Amdreelli, F ;
Saintillan, Y ;
Grondin, P ;
Kahn, A ;
Thorens, B ;
Vaulont, S ;
Viollet, B .
DIABETES, 2005, 54 (05) :1331-1339
[5]
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state [J].
Foretz, Marc ;
Hebrard, Sophie ;
Leclerc, Jocelyne ;
Zarrinpashneh, Elham ;
Soty, Maud ;
Mithieux, Gilles ;
Sakamoto, Kei ;
Andreelli, Fabrizio ;
Viollet, Benoit .
JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (07) :2355-2369
[6]
AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside [J].
Guigas, Bruno ;
Taleux, Nellie ;
Foretz, Marc ;
Detaille, Dominique ;
Andreelli, Fabrizio ;
Viollet, Benoit ;
Hue, Louis .
BIOCHEMICAL JOURNAL, 2007, 404 (03) :499-507
[7]
AMPK phosphorylation of raptor mediates a metabolic checkpoint [J].
Gwinn, Dana M. ;
Shackelford, David B. ;
Egan, Daniel F. ;
Mihaylova, Maria M. ;
Mery, Annabelle ;
Vasquez, Debbie S. ;
Turk, Benjamin E. ;
Shaw, Reuben J. .
MOLECULAR CELL, 2008, 30 (02) :214-226
[8]
Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation [J].
Hawley, Simon A. ;
Ross, Fiona A. ;
Chevtzoff, Cyrille ;
Green, Kevin A. ;
Evans, Ashleigh ;
Fogarty, Sarah ;
Towler, Mhairi C. ;
Brown, Laura J. ;
Ogunbayo, Oluseye A. ;
Evans, A. Mark ;
Hardie, D. Grahame .
CELL METABOLISM, 2010, 11 (06) :554-565
[9]
AMP-Activated protein kinase and autophagy [J].
Meijer, Alfred J. ;
Codogno, Patrice .
AUTOPHAGY, 2007, 3 (03) :238-240
[10]
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives [J].
Viollet, B. ;
Guigas, B. ;
Leclerc, J. ;
Hebrard, S. ;
Lantier, L. ;
Mounier, R. ;
Andreelli, F. ;
Foretz, M. .
ACTA PHYSIOLOGICA, 2009, 196 (01) :81-98