Biological applications of quantum dots

被引:904
作者
Jamieson, Timothy
Bakhshi, Raheleh
Petrova, Daniela
Pocock, Rachael
Imani, Mo
Seifalian, Alexander M.
机构
[1] UCL, BTEC, London NW3 2PF, England
[2] Polymer & Petrochem Inst, Dept Novel Drug Delivery Syst, Tehran, Iran
[3] Royal Free Hampstead NHS Trust Hosp, London, England
基金
英国工程与自然科学研究理事会;
关键词
quantum dot; nanocrystal; fluorescence imaging; gene technology; tumor imaging; polymer and nanomaterial;
D O I
10.1016/j.biomaterials.2007.07.014
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Quantum dots (QDs) are a novel class of inorganic fluorophore which are gaining widespread recognition as a result of their exceptional photophysical properties. They are rapidly being applied to existing and emerging technologies, and could have an important role in many areas. Significant challenges remain, however, which must be understood and more fully defined before they can be widely validated. This review provides on overview of QD technology, covering QD characteristics, synthesis methods, and the applications in which they have been put to use. The influence of synthesis methods on QD characteristics and their subsequent suitability to different applications is discussed, and a broad outline of the technologies into which they have been incorporated is presented, and the relative merits and weaknesses of their incorporation are evaluated. The potential for further development, and inclusion in other technologies is also discussed, and barriers restricting further progress specified, particularly with regard to the poorly understood surface chemistry of QDs, the potential for alteration of function of biological molecules when complexed with QDs, and on a larger scale the significant potential for cytotoxicity both in vitro and in vivo. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:4717 / 4732
页数:16
相关论文
共 152 条
  • [1] Real-time detection of virus particles and viral protein expression with two-color nanoparticle probes
    Agrawal, A
    Tripp, RA
    Anderson, LJ
    Nie, SM
    [J]. JOURNAL OF VIROLOGY, 2005, 79 (13) : 8625 - 8628
  • [2] Nanocrystal targeting in vivo
    Åkerman, ME
    Chan, WCW
    Laakkonen, P
    Bhatia, SN
    Ruoslahti, E
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) : 12617 - 12621
  • [3] Semiconductor clusters, nanocrystals, and quantum dots
    Alivisatos, AP
    [J]. SCIENCE, 1996, 271 (5251) : 933 - 937
  • [4] Noninvasive imaging of quantum dots in mice
    Ballou, B
    Lagerholm, BC
    Ernst, LA
    Bruchez, MP
    Waggoner, AS
    [J]. BIOCONJUGATE CHEMISTRY, 2004, 15 (01) : 79 - 86
  • [5] Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy
    Bharali, DJ
    Lucey, DW
    Jayakumar, H
    Pudavar, HE
    Prasad, PN
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (32) : 11364 - 11371
  • [6] Nanoparticle and targeted systems for cancer therapy
    Brannon-Peppas, L
    Blanchette, JO
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (11) : 1649 - 1659
  • [7] Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation
    Brown, E
    McKee, T
    diTomaso, E
    Pluen, A
    Seed, B
    Boucher, Y
    Jain, RK
    [J]. NATURE MEDICINE, 2003, 9 (06) : 796 - 800
  • [8] Semiconductor nanocrystals as fluorescent biological labels
    Bruchez, M
    Moronne, M
    Gin, P
    Weiss, S
    Alivisatos, AP
    [J]. SCIENCE, 1998, 281 (5385) : 2013 - 2016
  • [9] Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects
    Cai, WB
    Shin, DW
    Chen, K
    Gheysens, O
    Cao, QZ
    Wang, SX
    Gambhir, SS
    Chen, XY
    [J]. NANO LETTERS, 2006, 6 (04) : 669 - 676
  • [10] Calvo P, 1997, J APPL POLYM SCI, V63, P125, DOI 10.1002/(SICI)1097-4628(19970103)63:1<125::AID-APP13>3.0.CO