High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma

被引：48

作者：

Akamatsu, Norihiko

Yamada, Yasuaki

Hasegawa, Hiroo

Makabe, Koki

Asano, Ryutaro

Kumagai, Izumi

Murata, Ken

Maizum, Yoshitaka

Tsukasaki, Kunihiro

Tsuruda, Kazuto

Sugahara, Kazuyuki

AtogaMi, Sunao

Yanagihara, Katsunori

Kamihira, Shimeru

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Lab Med, Nagasaki 8528501, Japan

[2] Tohoku Univ, Grad Sch Engn, Dept Biomol Engn, Aoba Ku, Sendai, Miyagi 9809579, Japan

[3] Nagasaki Univ, Grad Sch Biomed Sci, Atom Bomb Dis, Dept hematol & Mol Med, Nagasaki 8528501, Japan

[4] Tottori Univ, Fac Med, Div Clin Lab Med & Hematol, Tottori 6838504, Japan

来源：

CANCER LETTERS | 2007年 / 256卷 / 02期

关键词：

IL-21; apoptosis; follicular lymphoma; Bcl-2;

D O I：

10.1016/j.canlet.2007.06.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(l4-,l8)(q32;q2l), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：196 / 206

页数：11

相关论文

共 32 条

[1] CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2 [J].

Ahmed-Choudhury, J ;

Williams, KT ;

Young, LS ;

Adams, DH ;

Afford, SC .

CELLULAR SIGNALLING, 2006, 18 (04) :456-468

[2] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[3] Antitumor activity of interleukin-21 prepared by novel refolding procedure from inclusion bodies expressed in Escherichia coli [J].

Asano, R ;

Kudo, T ;

Makabe, K ;

Tsumoto, K ;

Kumagai, I .

FEBS LETTERS, 2002, 528 (1-3) :70-76

[4] Cutting edge:: The common γ-chain is an indispensable subunit of the IL-21 receptor complex [J].

Asao, H ;

Okuyama, C ;

Kumaki, S ;

Ishii, N ;

Tsuchiya, S ;

Foster, D ;

Sugamura, K .

JOURNAL OF IMMUNOLOGY, 2001, 167 (01) :1-5

[5] Interleukin-21 is a growth and survival factor for human myeloma cells [J].

Brenne, AT ;

Ro, TB ;

Waage, A ;

Sundan, A ;

Borset, M ;

Hjorth-Hansen, H .

BLOOD, 2002, 99 (10) :3756-3762

[6] The role of STATs in transcriptional control and their impact on cellular function [J].

Bromberg, J ;

Darnell, JE .

ONCOGENE, 2000, 19 (21) :2468-2473

[7] Stat3 as an oncogene [J].

Bromberg, JF ;

Wrzeszczynska, MH ;

Devgan, G ;

Zhao, YX ;

Pestell, RG ;

Albanese, C ;

Darnell, JE .

CELL, 1999, 98 (03) :295-303

[8] Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis [J].

Chin, YE ;

Kitagawa, M ;

Kuida, K ;

Flavell, RA ;

Fu, XY .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (09) :5328-5337

[9] Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells [J].

de Totero, D ;

Meazza, R ;

Zupo, S ;

Cutrona, G ;

Matis, S ;

Colombo, M ;

Balleari, E ;

Pierri, I ;

Fabbi, M ;

Capaia, M ;

Azzarone, B ;

Gobbi, M ;

Ferrarini, M ;

Ferrini, S .

BLOOD, 2006, 107 (09) :3708-3715

[10] IL-21 induces tumor rejection by specific CTL and IFN-γ-dependent CXC chemokines in syngeneic mice [J].

Di Carlo, E ;

Comes, A ;

Orengo, AM ;

Rosso, O ;

Meazza, R ;

Musiani, P ;

Colombo, MP ;

Ferrini, S .

JOURNAL OF IMMUNOLOGY, 2004, 172 (03) :1540-1547

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