Head and Neck Cancer Proteomic Advances and Biomarker Achievements

被引：56

作者：

Berto Rezende, Taia Maria ^{[1
]}

Freire, Mirna de Souza ^{[1
]}

Franco, Octavio Luiz ^{[1
]}

机构：

[1] Univ Catolica Brasilia, Ctr Prote & Biochem Anal, Brasilia, DF, Brazil

来源：

CANCER | 2010年 / 116卷 / 21期

关键词：

head and neck cancer; proteomics; cancer risk factors; cancer pathogenesis; diagnostic biomarkers; SQUAMOUS-CELL CARCINOMA; EPIDERMAL-GROWTH-FACTOR; 2-DIMENSIONAL GEL-ELECTROPHORESIS; LASER CAPTURE MICRODISSECTION; ORAL EPITHELIAL DYSPLASIA; IMAGING MASS-SPECTROMETRY; UPPER AERODIGESTIVE TRACT; PROTEIN PROFILE ANALYSIS; NASOPHARYNGEAL CARCINOMA; FACTOR RECEPTOR;

D O I：

10.1002/cncr.25245

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumors of the head and neck comprise an important neoplasia group, the incidence of which is increasing in many parts of the world. Recent advances in diagnostic and therapeutic techniques for these lesions have yielded novel molecular targets, uncovered signal pathway dominance, and advanced early cancer detection. Proteomics is a powerful tool for investigating the distribution of proteins and small molecules within biological systems through the analysis of different types of samples. The proteomic profiles of different types of cancer have been studied, and this has provided remarkable advances in cancer understanding. This review covers recent advances for head and neck cancer; it encompasses the risk factors, pathogenesis, proteomic tools that can help in understanding cancer, and new proteomic findings in this type of cancer. Cancer 2010;116:4914-25. (C) 2010 American Cancer Society

引用

页码：4914 / 4925

页数：12

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